Idarucizumab reverses the anticoagulant effect of dabigatran within minutes in patient study
What Is Idarucizumab?
Idarucizumab is a drug that reverses the effects of another medicine called dabigatran (Pradaxa). Dabigatran is used to prevent blood clots and strokes in people with certain heart disorders. Because the medicine keeps the blood from clotting, people taking dabigatran can bleed more easily.
Idarucizumab is used during a medical emergency to treat severe or uncontrolled bleeding that has been caused by taking dabigatran.
Idarucizumab is also used when an emergency surgery or other invasive medical procedure is needed in a person who takes dabigatran.
Idarucizumab may also be used for purposes not listed in this medication guide.
In an emergency situation it may not be possible to tell your caregivers about your health conditions. Make sure any doctor caring for you afterward knows you have received this medicine.
If possible before you receive idarucizumab, tell your doctor if you have hereditary fructose intolerance.Idarucizumab contains sorbitol (a sugar alcohol). Sorbitol can cause serious or life-threatening metabolic problems in people with hereditary fructose intolerance.
In an emergency situation it may not be possible to tell your caregivers if you are pregnant or breast-feeding. Make sure any doctor caring for your pregnancy or your baby knows you have received this medicine.
Idarucizumab Side Effects
Get emergency medical help if you havesigns of an allergic reaction:hives, itching; difficult breathing; swelling of your face, lips, tongue, or throat.
When the effects of dabigatran are reversed, you will not be protected against blood clots. Because of this, you may be susceptible to the effects of your underlying disease.Until you start taking dabigatran again, watch for signs and symptoms of blood clots, such as:
- sudden numbness or weakness (especially on one side of the body);
- problems with vision or speech;
- chest pain, wheezing, coughing up blood; or
- pain, swelling, warmth, or redness in one or both legs.
After you receive idarucizumab, tell your caregivers right away if you have:
- any bleeding that will not stop;
- lung problems--fever, chills, cough with yellow or green mucus, chest pain, feeling short of breath; or
- low potassium--leg cramps, constipation, irregular heartbeats, fluttering in your chest, increased thirst or urination, numbness or tingling, muscle weakness or limp feeling.
Common side effects may include:
- confusion, headache;
- fever; or
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Follow your doctor's instructions about any restrictions on food, beverages, or activity.
Other drugs may interact with idarucizumab, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell each of your health care providers about all medicines you use now and any medicine you start or stop using.
Idarucizumab is injected into a vein through an IV. A healthcare provider will give you this injection.
After you receive idarucizumab, you may need follow-up blood tests to help your doctor determine how quickly your blood is clotting.
Once your condition is stable, you may need to restart dabigatran to prevent blood clots.Carefully follow your doctor's instructions about how soon to start taking your medicine(s) again.
Since idarucizumab is given by a healthcare professional in a medical setting, an overdose is unlikely to occur.
Since idarucizumab is given by a healthcare professional in an emergency setting, you are not likely to miss a dose.
Copyright 1996-2019 Cerner Multum, Inc.
Video: How to Pronounce Idarucizumab (Praxbind) (Memorizing Pharmacology Extended Explanation)
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